I've done this drive a bunch. 2 main options - I5 to 50, or 97 to 395.
I-5 south to Sacramento then east on 50 up towards Tahoe. IMO, this route the roads are in better shape, but more traffic, and the passes are tougher if you have a mediocre tow rig. The Siskious and Hwy 50 are pretty...